Single-Cell Transcriptome Analysis Highlights a Role for Neutrophils and Inflammatory Macrophages in the Pathogenesis of Severe COVID-19

Single-Cell Transcriptome Analysis Highlights a Role

for Neutrophils and Inflammatory Macrophages in

the Pathogenesis of Severe COVID-19

bronchoalveolar lavageのsingule cell

2 healthy

3 mild

5 severe

neutrophilとmacrophage cluster 1がsevereに特徴的

IFITM2, IFITM1, H3F3B, SAT1, and S100A8 gene signatures were highly associated with neutrophils

CCL8, CCL3, CCL2, KLF6, and SPP1 were associated with macrophage cluster-1